Wednesday, 22 May 2013    HomeAbout UsContact Us    









You are here: Home Research Ginger


Aqueous Extract of Ginger Shows Antiproliferative Activity Through Disruption of Microtubule Network of Cancer Cells
Posted by Admin, Senior Editor in Ginger
Authored by PubMed
Topics: Ginger Cancer

  Mail To Friend    Printer Friendly Bookmark and Share

Ginger is an herb. The rhizome (underground stem) is used as a spice and also as a medicine. It can be used fresh, dried and powdered, or as a juice or oil. Ginger is commonly used to treat various types of "stomach problems," including motion sickness, morning sickness, colic, upset stomach, gas, diarrhea, nausea and vomiting after surgery, as well as loss of appetite. Other uses include treating upper respiratory tract infections, cough, and bronchitis.

Choudhury D, Das A, Bhattacharya A, Chakrabarti G. Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells. 1. Food Chem Toxicol. 2010 Oct;48(10):2872-80. Epub 2010 Jul 18.
Ginger has a long history of use as traditional medicine for varied human disease. Our present study has shown that the aqueous extract of ginger (GAE) interacts directly with cellular microtubules and disrupts its structure and induces apoptosis of cancer cells as well. The IC(50) values of GAE, as determined from cell viability experiment on human non-small lung epithelium cancer (A549) cells and human cervical epithelial carcinoma (HeLa), were 239.4+7.4 and 253.4+8.9 ?g/ml, respectively. It has been found that the apoptosis of A549 cells by GAE is mediated by up regulation of tumor suppressor gene p53 and alteration of the normal Bax/Bcl-2 ratio followed by down regulation of cellular pro-caspase3. The morphological change of cells upon GAE treatment has also been demonstrated. Both the structural and functional properties of tubulin and microtubule were lost, as confirmed by both ex vivo and invitro experiments. The major component of GAE is poly-phenols (around 2.5%), which consist of ~80% flavones and flavonols. Poly-phenolic compounds are well known to have anti-mitotic properties, and may be further screened for the development of a potential anti-cancer agent.


Link to this article:   Show: HTML LinkFull LinkShort Link
Share or Bookmark this page: You will need to have an account with the selected service in order to post links or bookmark this page.

                 
  
Subscribe via RSS or email:
Follow us through RSS or email. Click the RSS icon to subscribe to our feed.

     
  

Related Articles:
Add a Comment
You must be registered and logged in to comment.





Visit Vaccines.Me for information and education on vaccination.


Latest Articles
Eat Less and Live Heathier and Longer?
Efficacy of a Herbal Extract Gel in the Treatment of Gingivitis: A Clinical Study
Pomegranate Materials Inhibit Flagellin Gene Expression and Flagellar-Propelled Motility of Uropathogenic Escherichia Coli Strain CFT073
Anti-Inflammatory Effects of Pomegranate (Punica Granatum L.) Husk Ellagitannins in Caco-2 Cells, an in Vitro Model of Human Intestine
The Effect of Commiphora Molmol (Myrrh) in Treatment of Trichomoniasis Vaginalis Infection
Aldose Reductase Inhibitory Activity and Antioxidant Capacity of Pomegranate Extracts
Pomegranate Peel and Fruit Extracts: A Review of Potential Anti-Inflammatory and Anti-Infective Effects
Dietary Polyphenols and Mechanisms of Osteoarthritis
Pomegranate Phytoconstituents Blunt the Inflammatory Cascade in a Chemically Induced Rodent Model of Hepatocellular Carcinogenesis
Current Nutraceuticals in the Management of Osteoarthritis: A Review

Pages
No pages found.

Most Popular
Garlic, Honey and Apple Cider Vinegar: Must Have Excellent Home Remedy
How To Eat Fruit Properly
Ibn al-Qayyim: Henna Has Many Benefits from Treating Headaches to Burns
Rocket: A Spicy Salad Leaf With Potent Health Benefits
Why We Need Protein in our Diets
Five Superfoods You Should Be Eating Everyday
Deodorant And Anti-Perspirant Dangers - Do You Know What You're Putting Under Your Armpits?
What Foods Are Good For Your Eyesight?
Foods for Healthy Hair
The Different Kinds Of Exercises Your Body Needs

Archives (View more)
2012 • October
2012 • August
2012 • January
2011 • December
2011 • November
2011 • October
2011 • September
2011 • August
2011 • July
2011 • June
2011 • May
2011 • April


Copyright © 2013 . All rights reserved. RSSTagsPrivacyLegal and Terms of Use