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A Compound Herbal Preparation (CHP) in the Treatment of Children With ADHD: A Randomized Controlled Trial

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Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. 1. J Atten Disord. 2010 Nov;14(3):281-91. Epub 2010 Mar 12.

OBJECTIVE: Evaluation of the efficacy of a patented, compound herbal preparation (CHP) in improving attention, cognition, and impulse control in children with ADHD. METHOD: Design: A randomized, double-blind, placebo-controlled trial. Setting: University-affiliated tertiary medical center. Participants: 120 children newly diagnosed with ADHD, meeting DSM-IV criteria. Intervention: Random assignment to the herbal treatment group (n = 80) or control group (placebo; n = 40); 73 patients in the treatment group (91%) and 19 in the control group (48%) completed the 4-month trial. Outcome measure: Test of Variables of Attention (TOVA) administered before and after the treatment period; overall score and 4 subscales. RESULTS: The treatment group showed substantial, statistically significant improvement in the 4 subscales and overall TOVA scores, compared with no improvement in the control group, which persisted in an intention-to-treat analysis. CONCLUSIONS: The well-tolerated CHP demonstrated improved attention, cognition, and impulse control in the intervention group, indicating promise for ADHD treatment in children.