Advertisement. Report if inappropriate.
You are here: Home Research

Pomegranate Materials Inhibit Flagellin Gene Expression and Flagellar-Propelled Motility of Uropathogenic Escherichia Coli Strain CFT073

Posted by Admin on Thursday, August 30, 2012
© Authored by PubMed
© HealthyMuslim. See Terms and Conditions

 Copy Link
   Email    Print 


Asadishad B, Hidalgo G, Tufenkji N. Pomegranate materials inhibit flagellin gene expression and flagellar-propelled motility of uropathogenic Escherichia coli strain CFT073. 1. FEMS Microbiol Lett. 2012 Sep;334(2):87-94. doi: 10.1111/j.1574-6968.2012.02622.x. Epub 2012 Jul 12.
This report describes the inhibitory effect of pomegranate rind extract (PGRE) on the motility of uropathogenic Escherichia coli (UPEC), a common agent of uncomplicated urinary tract infections (UTIs). To this end, a fliC-lux reporter, as well as Western blot analysis and scanning electron microscopy, was used to demonstrate that when UPEC strain CFT073 is exposed to PGRE, expression of the flagellin gene, fliC, and flagellin production decrease. In agreement with these results, the swimming and swarming motilities of UPEC were observed to be hindered in the presence of PGRE. To evaluate the effect of other pomegranate materials (PMs), the hydrolysable tannins in pomegranate (PG; punicalagin) and pomegranate fruit powder (PGP) were also investigated. Of the materials tested, PGRE had the strongest inhibitory effect on fliC expression and motility. Moreover, a fractionation of PGRE showed fractions with a molecular weight between 1000 and 3000 kDa to be the strongest inhibitors of fliC expression. Because flagellum-mediated motility has been suggested to enable UPEC to disseminate to the upper urinary tract; we propose that PGRE might be therapeutically beneficial in the treatment and prevention of UTIs.


Link to this article:   Show: HTML LinkFull LinkShort Link
Share or Bookmark this page: You will need to have an account with the selected service in order to post links or bookmark this page.

                 
  
Subscribe via RSS or email:
Follow us through RSS or email. Click the RSS icon to subscribe to our feed.

     
  

Related Articles:
Add a Comment
You must be registered and logged in to comment.
Advertisement. Report if inappropriate.
Most Popular

Latest Articles

Popular Subjects
fluoridewater fluoridationcolicfruitexercisetoothpastealmondsmilkpHalkalineacidVitamin Ccancerlinus paulingwatercell phonemobile phoneraw milkaspartamesweetenersuperfoodsbrainlong lifelive longlongevityresveratrolblueberriesraspberriesgreen teaavocadosfatsnutritiondigestion research

Health, fitness and longevity
 Based upon the principles of health
 in the Qur'an and Prophetic Traditions.
HealthyMuslim.Com

There are two bounties in which
most people lose out: good health
and free time. Al-Bukhari.
The information on this site is provided for educational purposes only. It is not intended as a substitute for professional advice of any kind.