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Anti-Hyperlipidemic Activity of Withania Coagulans in Streptozotocin-Induced Diabetes: A Potent Anti-Atherosclerotic Agent

Posted by Admin on Thursday, August 16, 2012
Authored by PubMed

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Ashwagandha is an exotic Indian herb which has remarkable stress-relieving properties. In addition to its excellent protective effects on the nervous system, ashwaganDHA may be a promising alternative treatment for a variety of degenerative diseases such as Alzheimer's and Parkinson's. AshwaganDHA has powerful antioxidant properties that seek and destroy the free radicals that have been implicated in aging and numerous disease states. Even more remarkable, emerging evidence suggests that ashwaganDHA has anti-cancer benefits as well.

Saxena B. Anti-hyperlipidemic activity of Withania coagulans in streptozotocin-induced diabetes: A potent anti-atherosclerotic agent. 1. Drug Discov Ther. 2010 Oct;4(5):334-40.
Dyslipidemia is one of the most common complications in diabetes mellitus, which increases risk of premature atherosclerosis. Drugs having antihyperlipidemic activity in addition to their hypoglycemic effect in diabetes may be suitable anti-atherosclerotic agents in diabetic patients. The present study was aimed to investigate the anti-atherosclerotic activity of an aqueous extract of Withania coagulans (AWC) in terms of atherogenic index (AI) in normal and streptozotocin (STZ)-induced diabetes. AWC (1,000 mg/kg body weight, BW) was orally administrated in normal and STZ (70 mg/kg)-induced diabetic rats and levels of glucose, total cholesterol (CHL), high density lipoprotein (HDL)-cholesterol and triglyceride (TG) levels in the plasma were analyzed spectrophotometrically. BW was measured and AI was calculated in each group. Results show that after sub-chronic dosing, AWC reduced plasma glucose levels both in normal and diabetic rats, while significantly decreasing plasma levels of CHL, HDL and TG only in STZ-induced diabetic rats. Repeated administration of AWC also significantly decreased AI and prevented weight loss in STZ-induced diabetic animals. Hence, AWC showed anti-hyperlipidemic activity in diabetic rats and was suggested to be a suitable candidate for the treatment of atherosclerosis associated with diabetes.


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