You are here: Home Research Ashwagandha

Anti-Hyperlipidemic Activity of Withania Coagulans in Streptozotocin-Induced Diabetes: A Potent Anti-Atherosclerotic Agent

Posted by Admin on Thursday, August 16, 2012
Authored by PubMed

 Copy Link
   Email    Print 
Ashwagandha is an exotic Indian herb which has remarkable stress-relieving properties. In addition to its excellent protective effects on the nervous system, ashwaganDHA may be a promising alternative treatment for a variety of degenerative diseases such as Alzheimer's and Parkinson's. AshwaganDHA has powerful antioxidant properties that seek and destroy the free radicals that have been implicated in aging and numerous disease states. Even more remarkable, emerging evidence suggests that ashwaganDHA has anti-cancer benefits as well.

Saxena B. Anti-hyperlipidemic activity of Withania coagulans in streptozotocin-induced diabetes: A potent anti-atherosclerotic agent. 1. Drug Discov Ther. 2010 Oct;4(5):334-40.
Dyslipidemia is one of the most common complications in diabetes mellitus, which increases risk of premature atherosclerosis. Drugs having antihyperlipidemic activity in addition to their hypoglycemic effect in diabetes may be suitable anti-atherosclerotic agents in diabetic patients. The present study was aimed to investigate the anti-atherosclerotic activity of an aqueous extract of Withania coagulans (AWC) in terms of atherogenic index (AI) in normal and streptozotocin (STZ)-induced diabetes. AWC (1,000 mg/kg body weight, BW) was orally administrated in normal and STZ (70 mg/kg)-induced diabetic rats and levels of glucose, total cholesterol (CHL), high density lipoprotein (HDL)-cholesterol and triglyceride (TG) levels in the plasma were analyzed spectrophotometrically. BW was measured and AI was calculated in each group. Results show that after sub-chronic dosing, AWC reduced plasma glucose levels both in normal and diabetic rats, while significantly decreasing plasma levels of CHL, HDL and TG only in STZ-induced diabetic rats. Repeated administration of AWC also significantly decreased AI and prevented weight loss in STZ-induced diabetic animals. Hence, AWC showed anti-hyperlipidemic activity in diabetic rats and was suggested to be a suitable candidate for the treatment of atherosclerosis associated with diabetes.

Link to this article:   Show: HTML LinkFull LinkShort Link
Share or Bookmark this page: You will need to have an account with the selected service in order to post links or bookmark this page.

Subscribe via RSS or email:
Follow us through RSS or email. Click the RSS icon to subscribe to our feed.


Related Articles:
Add a Comment
You must be registered and logged in to comment.
Most Popular

Latest Articles

Popular Subjects
fluoridewater fluoridationcolicfruitexercisetoothpastealmondsmilkpHalkalineacidVitamin Ccancerlinus paulingwatercell phonemobile phoneraw milkaspartamesweetenersuperfoodsbrainlong lifelive longlongevityresveratrolblueberriesraspberriesgreen teaavocadosfatsnutritiondigestion research

Health, fitness and longevity
 Based upon the principles of health
 in the Qur'an and Prophetic Traditions.

There are two bounties in which
most people lose out: good health
and free time. Al-Bukhari.
The information on this site is provided for educational purposes only. It is not intended as a substitute for professional advice of any kind.