Thursday, 18 October 2018    HomeAbout UsContact Us    









You are here: Home Research Nigella Sativa (Black Seed)


Can Methanolic Extract of Nigella Sativa Seed Affect Glyco-Regulatory Enzymes in Experimental Hepatocellular Carcinoma
Posted by HealthyMuslim, in Nigella Sativa (Black Seed)
Authored by PubMed
Topics: Nigella Sativa Black Seed

  Mail To Friend    Printer Friendly Bookmark and Share

Abdel-Hamid NM, Abdel-Ghany MI, Nazmy MH, Amgad SW. Can methanolic extract of nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma? 1. Environ health Prev Med. 2012 Jul 6. [Epub ahead of print]
BACKGROUND AND AIM: To investigate the possible modulating role of "nigella sativa" (NS), a plant commonly used in Egyptian traditional medicine, on premalignant perturbations in three glycol-regulatory enzymes in an experimental rat model of hepatocellular carcinoma (HCC). METHODS: Thirty-six (36) male albino rats were divided into four groups (n = 9). Group 1 served as a normal control, group 2 was treated with methanolic extract of nigella sativa (MENS) (1?g/kg/day, orally) for 14?weeks, group 3 received a single intraperitoneal dose of diethyl nitrosamine (DENA) (200?mg/kg), followed 2?weeks later by a subcutaneous injection of carbon tetrachloride (CCl(4), 3?ml/kg/week/6?weeks) and group IV was treated with MENS for 2?weeks prior to administration of the carcinogenic combination (DENA?+?CCl(4), as in group 3) until the end of the experiment. The total period of the experiment was 14?weeks. RESULTS: In the DENA?+?CCl(4)-treated group, there was a significant increase in the relative liver weight, serum alpha fetoprotein level and the activities of hexokinase, glyceraldehyde phosphate dehydrogenase and glucose 6 phosphate dehydrogenase in both the serum and liver homogenate; this was accompanied by a subsequent decrease in body weight. Pre-treatment with MENS significantly maintained these parameters close to the normal condition. CONCLUSION: Based on these results, we conclude that MENS has a chemo-preventive effect against the progression into liver malignancy through its modulation of the energy metabolic pathways (i.e. glycolysis) that may be involved in hepatocarcinogenesis.


Link to this article:   Show: HTML LinkFull LinkShort Link
Share or Bookmark this page: You will need to have an account with the selected service in order to post links or bookmark this page.

                 
  
Subscribe via RSS or email:
Follow us through RSS or email. Click the RSS icon to subscribe to our feed.

     
  

Related Articles:
Add a Comment
You must be registered and logged in to comment.





Visit Vaccines.Me for information and education on vaccination.


Latest Articles
Some Notes of Advice on Health, Disease and 'Medicine'
Cooking With Vegetable Oils Releases Toxic Cancer-Causing Chemicals, Say Experts
Cancer Simplified: Part 5 - The Initiators and Promoters of Cancer
Cancer Simplified: Part 4 - The Immune System's In-Built Anti-Cancer Mechanism
Cancer Simplified: Part 3 - Cancer Is Simply a Failure of the Immune System
Cancer Simplified: Part 2 - An Analogy for Different Perceptions About Treatment of Cancer
Cancer Simplified: Part 1 - What Is Cancer and How Does It Develop?
Honey and Anti-Biotic Resistance: A New Approach!
On the Rejection of Hijaamah by the Physicians (Shaykh Muhammad Bin Ibraaheem Aal Al-Shaykh)
How to Limit Efffects of Bisphenol-A Upon Children

Pages
No pages found.

Most Popular
Garlic, Honey and Apple Cider Vinegar: Must Have Excellent Home Remedy
How To Eat Fruit Properly
Rocket: A Spicy Salad Leaf With Potent Health Benefits
Ibn al-Qayyim: Henna Has Many Benefits from Treating Headaches to Burns
Talbina: Relaxation For the Heart of the Sick Person
Why We Need Protein in our Diets
Five Superfoods You Should Be Eating Everyday
Deodorant And Anti-Perspirant Dangers - Do You Know What You're Putting Under Your Armpits?
The Different Kinds Of Exercises Your Body Needs
What Foods Are Good For Your Eyesight?

Archives (View more)
2016 • January
2015 • November
2014 • March
2014 • February
2013 • October
2012 • October
2012 • August
2012 • January
2011 • December
2011 • November
2011 • October
2011 • September


Copyright © 2018 . All rights reserved. RSSTagsPrivacyLegal and Terms of Use Good Resource on Basic Arabic Grammar