Advertisement. Report if inappropriate.

Can Methanolic Extract of Nigella Sativa Seed Affect Glyco-Regulatory Enzymes in Experimental Hepatocellular Carcinoma

Posted by HealthyMuslim on Wednesday, August 15, 2012
© Authored by PubMed
© HealthyMuslim. See Terms and Conditions

 Copy Link
   Email    Print 
Abdel-Hamid NM, Abdel-Ghany MI, Nazmy MH, Amgad SW. Can methanolic extract of nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma? 1. Environ health Prev Med. 2012 Jul 6. [Epub ahead of print]
BACKGROUND AND AIM: To investigate the possible modulating role of "nigella sativa" (NS), a plant commonly used in Egyptian traditional medicine, on premalignant perturbations in three glycol-regulatory enzymes in an experimental rat model of hepatocellular carcinoma (HCC). METHODS: Thirty-six (36) male albino rats were divided into four groups (n = 9). Group 1 served as a normal control, group 2 was treated with methanolic extract of nigella sativa (MENS) (1?g/kg/day, orally) for 14?weeks, group 3 received a single intraperitoneal dose of diethyl nitrosamine (DENA) (200?mg/kg), followed 2?weeks later by a subcutaneous injection of carbon tetrachloride (CCl(4), 3?ml/kg/week/6?weeks) and group IV was treated with MENS for 2?weeks prior to administration of the carcinogenic combination (DENA?+?CCl(4), as in group 3) until the end of the experiment. The total period of the experiment was 14?weeks. RESULTS: In the DENA?+?CCl(4)-treated group, there was a significant increase in the relative liver weight, serum alpha fetoprotein level and the activities of hexokinase, glyceraldehyde phosphate dehydrogenase and glucose 6 phosphate dehydrogenase in both the serum and liver homogenate; this was accompanied by a subsequent decrease in body weight. Pre-treatment with MENS significantly maintained these parameters close to the normal condition. CONCLUSION: Based on these results, we conclude that MENS has a chemo-preventive effect against the progression into liver malignancy through its modulation of the energy metabolic pathways (i.e. glycolysis) that may be involved in hepatocarcinogenesis.


Link to this article:   Show: HTML LinkFull LinkShort Link
Share or Bookmark this page: You will need to have an account with the selected service in order to post links or bookmark this page.

                 
  
Subscribe via RSS or email:
Follow us through RSS or email. Click the RSS icon to subscribe to our feed.

     
  

Related Articles:
Add a Comment
You must be registered and logged in to comment.
Advertisement. Report if inappropriate.
Most Popular

Latest Articles

Popular Subjects
fluoridewater fluoridationcolicfruitexercisetoothpastealmondsmilkpHalkalineacidVitamin Ccancerlinus paulingwatercell phonemobile phoneraw milkaspartamesweetenersuperfoodsbrainlong lifelive longlongevityresveratrolblueberriesraspberriesgreen teaavocadosfatsnutritiondigestion research

Health, fitness and longevity
 Based upon the principles of health
 in the Qur'an and Prophetic Traditions.
HealthyMuslim.Com

There are two bounties in which
most people lose out: good health
and free time. Al-Bukhari.
The information on this site is provided for educational purposes only. It is not intended as a substitute for professional advice of any kind.