Research Summaries on Nigella Sativa (Black Seed) - Part 1

Posted by HealthyMuslim on Sunday, October 26, 2008
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This is a summary page of research papers published on nigella sativa, the black seed. In this list we will simply mention the results or conclusions of the research paper, trying to quote or summarize the stated conclusions in each paper.

"There is within the black seed a cure for every disease except death", From the statements of the Prophet (sallallaahu alayhi wa sallam), Sahih al-Bukhari, Chapter on medicine.

Note that these studies are based on both human and non-human subjects. Where it is the latter, it is an indication that further exploration in human subjects is an avenue that can be embarked upon to identify the effects of the black seed (nigella sativa) in those states.

Cardioprotective Effects of nigella sativa oil on Cyclosporine A-Induced Cardiotoxicity in Rats

The results of our study show that pre-treatment with N. sativa oil reduced the subsequent cyclosporine A injury in rat heart, demonstrated by normalized cardiac histopathology, decrease in lipid peroxidation, improvement in antioxidant enzyme status and cellular protein oxidation.
Basic Clin Pharmacol Toxicol. 2008 Sep 17.

This means: NS (nigella sativa) has a protective effect on the heart following its injury.

Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver

Our results suggest that nigella sativa treatment protects the rat liver against to hepatic ischemia-reperfusion injury.
World J Gastroenterol. 2008 Sep 7;14(33):5204-9.

This means: NS has a protective effect on potential liver injury caused by a (sudden) restrictive blood supply.

Antihypertensive effect of nigella sativa seed extract in patients with mild hypertension

The results suggest that the daily use of NS seed extract for 2 months may have a blood pressure-lowering effect in patients with mild HT (hypertension).
Fundam Clin Pharmacol. 2008 Aug;22(4):447-52.

This means: NS displays blood pressure-lowering effects in people with hypertension (high blood-pressure)

Role of nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats

Although the exact mechanisms involved in the protective role of nigella sativa against the initiation of colon carcinogenesis are not clearly understood, the results suggest that its inhibitory effects might depend on the combined competitive inhibition of various antioxidant constituents of this plant
Phytother Res. 2008 Oct;22(10):1311-23.

This means: NS and other molecules from the plant have a combined preventative effect against cancer initiation in the colon.

Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of nigella sativa and Phyllanthus niruri extract

At the end of treatment (Day 7), a significantly greater proportion of patients in the NSPN group than in the placebo group had their sore throat completely relieved. NSPN extract was also found to be safe and well tolerated in acute tonsillopharyngitis patients. This study proved significant benefits of NSPN extract in the treatment of acute tonsillopharyngitis as compared to placebo.
Int J Clin Pharmacol Ther. 2008 Jun;46(6):295-306.

This means: NS plays a role in the relief of sore throat.

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