Saremi A, Bahn G, Reaven PD; for the VADT Investigators. Progression of Vascular calcification Is Increased With Statin Use in the Veterans Affairs diabetes Trial (VADT). 1. diabetes Care. 2012 Aug 8. [Epub ahead of print]
OBJECTIVE: To determine the effect of statin use on progression of vascular calcification in type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS: Progression of coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) was assessed according to the frequency of statin use in 197 participants with T2DM. RESULTS: After adjustment for baseline CAC and other confounders, progression of CAC was significantly higher in more frequent statin users than in less frequent users (mean - SE, 8.2 - 0.5 mm(3) vs. 4.2 - 1.1 mm(3); P < 0.01). AAC progression was in general not significantly increased with more frequent statin use; in a subgroup of participants initially not receiving statins, however, progression of both CAC and AAC was significantly increased in frequent statin users. CONCLUSION: More frequent statin use is associated with accelerated coronary artery calcification in T2DM patients with advanced atherosclerosis.
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