BACKGROUND: stress has been found to significantly reduce the abilities of the immune system to fight infections. One of the ways to overcome the defects of the immune system is the strengthening of the defense reactions by nutrition. AIMS: TO EVALUATE IMMUNE ENHANCING EFFECTS OF THE FOLLOWING MATERIAL: WB365, a novel combination of ashwaganDHA (Withania somnifera) and Maitake (Grifola frondosa) extracts. RESULTS: We found that both glucan-rich maitake extract and WB365 caused a similar stimulation of phagocytic activity. Stress-induced increase of corticosterone production was blocked by feeding with ashwaganDHA extract and even more by WB365. Cytokine experiments showed that feeding with WB365 helped overcome the stress-related inhibition of IL-6, IL-12 and IFN-? production. CONCLUSION: This study clearly demonstrated that WB365, a combination of Maitake mushroom-derived glucan and ashwaganDHA extracts, has strong pleiotropic biological effects related to immune health and stress reduction.