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Note that these studies are based on both human and non-human subjects. Where it is the latter, it is an indication that further exploration in human subjects is an avenue that can be embarked upon to identify the effects of the black seed (nigella sativa) in those states.
The results of our study show that pre-treatment with N. sativa oil reduced the subsequent cyclosporine A injury in rat heart, demonstrated by normalized cardiac histopathology, decrease in lipid peroxidation, improvement in antioxidant enzyme status and cellular protein oxidation.Basic Clin Pharmacol Toxicol. 2008 Sep 17.
Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver
Our results suggest that nigella sativa treatment protects the rat liver against to hepatic ischemia-reperfusion injury.World J Gastroenterol. 2008 Sep 7;14(33):5204-9.
This means: NS has a protective effect on potential liver injury caused by a (sudden) restrictive blood supply.
Antihypertensive effect of nigella sativa seed extract in patients with mild hypertension
The results suggest that the daily use of NS seed extract for 2 months may have a blood pressure-lowering effect in patients with mild HT (hypertension).Fundam Clin Pharmacol. 2008 Aug;22(4):447-52.
Although the exact mechanisms involved in the protective role of nigella sativa against the initiation of colon carcinogenesis are not clearly understood, the results suggest that its inhibitory effects might depend on the combined competitive inhibition of various antioxidant constituents of this plantPhytother Res. 2008 Oct;22(10):1311-23.
This means: NS and other molecules from the plant have a combined preventative effect against cancer initiation in the colon.
Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of nigella sativa and Phyllanthus niruri extract
At the end of treatment (Day 7), a significantly greater proportion of patients in the NSPN group than in the placebo group had their sore throat completely relieved. NSPN extract was also found to be safe and well tolerated in acute tonsillopharyngitis patients. This study proved significant benefits of NSPN extract in the treatment of acute tonsillopharyngitis as compared to placebo.Int J Clin Pharmacol Ther. 2008 Jun;46(6):295-306.
This means: NS plays a role in the relief of sore throat.
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