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Modulatory Effects of Garlic, Ginger, Turmeric and Their Mixture on Hyperglycaemia, Dyslipidaemia and Oxidative Stress in Streptozotocin-Nicotinamide Diabetic Rats

Posted by Admin on Friday, August 17, 2012
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Topics: Ginger
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Ginger is an herb. The rhizome (underground stem) is used as a spice and also as a medicine. It can be used fresh, dried and powdered, or as a juice or oil. Ginger is commonly used to treat various types of "stomach problems," including motion sickness, morning sickness, colic, upset stomach, gas, diarrhea, nausea and vomiting after surgery, as well as loss of appetite. Other uses include treating upper respiratory tract infections, cough, and bronchitis.

Madkor HR, Mansour SW, ramadan G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. 1. Br J Nutr. 2011 Apr;105(8):1210-7. Epub 2010 Dec 10.
Spices which show hypoglycaemic, hypolipidaemic and antioxidant activities may have a role in the treatment of diabetes and its complications. The present study aimed to compare the modulatory effects of garlic, ginger, turmeric and their mixture on the metabolic syndrome and oxidative stress in streptozotocin (STZ)-nicotinamide diabetic rats. diabetes was induced in overnight fasted rats by a single intraperitoneal injection of STZ (65?mg/kg body weight) and nicotinamide (110?mg/kg body weight, 15?min before STZ injection). Diabetic rats orally received either distilled water (as vehicle) or 200?mg/kg body weight of garlic bulb, ginger rhizome or turmeric rhizome powder suspension separately or mixed together (GGT mixture) for twenty-eight consecutive days. The results showed that these spices and their mixture significantly alleviated (80-97?%, P?antioxidant defence system (31-52?%, especially GSH) and decreasing lipid peroxidation (60-97?%). The greatest modulation was seen in diabetic rats that received garlic and the GGT mixture (10-23?% more than that in the ginger and turmeric groups). In conclusion, garlic or the mix including garlic appears to have an impact on each of the measures more effectively than ginger and turmeric and may have a role in alleviating the risks of the metabolic syndrome and cardiovascular complications.


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