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MSG Is Linked to Obesity Recent research has shown that monosodium glutamate (MSG) causes weight gain and obesity in lab animals, and that it can have the same effect in humans. The research was reported in the journal obesity, and found that the food additive damaged the appetite regulation center in the hypothalamus (an area of the brain), causing leptin resistance. Leptin is a protein hormone that regulates energy intake and energy expenditure, including appetite and metabolism. Researchers conducted a cross-sectional study in China, and participants were told to add quantified amounts of MSG when preparing their foods. After adjusting for confounders including physical activity and total energy intake, the researchers found that MSG consumption was positively related to increases in body mass index.
MSG Can Cause brain Damage MSG is considered a neurotoxin, and many studies have linked this food additive to brain damage in animals. MSG is the sodium salt of glutamate, and glutamate is one of the more commonly known excitotoxins (another one is aspartame). Glutamate is a normal neurotransmitter in the brain, but only exists in the extracellular (outside the cell) fluid of the brain in very, very small concentrations. When the concentration of this transmitter rises, the neurons begin to fire abnormally, and the cells undergo this specialized process of delayed cell death, excitotoxicity. Studies have shown that these effects are subtle and develop over a long period of time, although some people have a greater sensitivity and can develop more severe symptoms of excitotoxicity. The many studies that provide the evidence for this are given below in the references. MSG and Macular Degeneration Studies show that MSG can cause macular degeneration (retinal degeneration). In a 2002 study, researchers found that when MSG was fed to laboratory animals for 3 months and 6 months, observable retinal damage was seen.
MSG Promotes Liver inflammation and Dysplasia In a 2008 study reported in the Journal of Autoimmunity, researchers reported that injecting MSG in mice lead to significant liver inflammation along with obesity and type 2 diabetes. Researchers looked at the long-term consequences of MSG on inflammation, by analyzing MSG injected mice and focusing in particular on liver pathology. They found that by the age of 6 and 12 months, all MSG treated mice developed liver inflammation and structural abnormal change (dysplasia), and lesions were detected in some cases.
MSG is a Widely-used Flavor Enhancer A lot of canned, processed and pre-packed food and fast food contains MSG, but it is frequently listed under various names on the food label. Some of the many names used are: hydrolyzed vegetable protein, autolyzed vegetable protein, textured vegetable protein, hydrolyzed yeast extract, autolyzed yeast extract, plant protein extract, sodium caseinate, calcium caseinate, yeast extract, textured whey protein, and textured soy protein. Even the terms spice and natural flavor can indicate the presence of MSG. The best way avoid MSG is by buying whole foods and preparing them at home. The next best thing is to read the labels and know the various disguises under which MSG is known, and avoid these foods. References
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