Naruszewicz M, Zapolska-Downar D, Ko[mider A, et al. Chronic intake of potato chips in humans increases the production of reactive oxygen radicals by leukocytes and increases plasma C-reactive protein: a pilot study. American Journal of Clinical nutrition 2009;89:773-7
Design: Fourteen healthy volunteers (mean age: 35 y; 8 women and 6 smokers of .20 cigarettes/d) were given 160 g of potato chips containing 157 mg of acrylamide daily for 4 wk. Results: An increase in acrylamide-hemoglobin adducts in blood was found in all the study subjects.
Concurrently, a significant increase (P < 0.01) in the oxidized LDL, high-sensitivity interleukin-6, high-sensitivity C-reactive protein, and -glutamyltransferase concentrations was observed in both smokers and nonsmokers. A significant increase in reactive oxygen radical production by monocytes, lymphocytes, and granulocytes and an increase in CD14 expression in macrophages (P < 0.001) were found after intake of potato chips. Twenty-eight days from the discontinuation of the experiment, the variables under study decreased to some extent. It has been shown also that acrylamide increases the production of reactive oxygen species in isolated human monocyte-macrophages in vitro and decreases the cellular glutathione concentration.
Conclusion: These novel findings seem to indicate that chronic ingestion of acrylamide-containing products induces a proinflammatory state, a risk factor for progression of atherosclerosis.
Acrylamide is classified by the International Agency for Research on cancer (IARC) as a probable human carcinogen . Numerous studies have found the carcinogenic effects of this chemical, which is found in foods rich in starch and that have been cooked at high temperatures. The research indicates that more acrylamide is formed at higher temperatures and at longer cooking times during frying, deep-frying or grilling food, but not from boiling.
Therefore, it is advisable to boil or steam food rather than cooking it at high temperatures, which also retains more nutrients. Also, avoid burning food during frying and grilling, and do not eat burned food.
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